U.S. patents available from 1976 to present.
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Method for treating xerostomia employing chewing gum containing relatively insoluble, hydrophobic, food-grade organic acid

Patent 4906455 Issued on March 6, 1990. Estimated Expiration Date: Icon_subject February 3, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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3151028

3632358

Long-lasting flavored chewing gum including chalk-free gum base
Patent #: 4064274
Issued on: 12/20/1977
Inventor: Mackay ,   et al.

Long-lasting flavored chewing gum
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Saliva stimulating chewing gum composition
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Issued on: 05/09/1978
Inventor: Ream, et al.

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Inventor: Ream ,   et al.

Gum emulsified liquid package for delivering and preserving liquid content in the mouth
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Issued on: 11/11/1980
Inventor: Cornell

Chewing gum
Patent #: 4400372
Issued on: 08/23/1983
Inventor: Muhler ,   et al.

Use of lactose-hydrolyzed whey in chewing gum
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Issued on: 10/30/1984
Inventor: Bakal ,   et al.

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Inventor

Assignee

Application

No. 306626 filed on 02/03/1989

US Classes:

424/48, CHEWING GUM TYPE514/440Only two ring sulfurs in the hetero ring

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Class

A61K 009/68

Abstract

A method for treating xerostomia, or dry mouth, not caused by exercising, employs a specially formulated chewing gum. The method involves chewing a sugarless gum which contains a relatively insoluble, hydrophobic, food-grade organic acid, such as adipic acid. Chewing the gum gradially releases the acid at a desirable linear rate over a period of about 20 to 30 minutes. Slow release of the acid from the gum results in an increase in salivary flow rate in xerostomia non-exercising patients having decreased salivary gland function.

Other References

  • G. Anneroth et al., Effect of Saliva Stimulants (Hybrin (R) and Malic Acid) on Cervical Root Surfaces in Vitro, Scand. J. Res., 88, 214-218, (1980)
  • C. M. Christensen et al., Effects of Pharmaologic Reductions in Salivary Flow on Taste Thresholds in Man, Arch. Oral Biol., 29, 17-23, (1984)
  • C. Dawes, Effects of Diet on Salivary Secretion and Composition, J. Dent. Res., 49, 1263-73, (1970)
  • E. J. Edmonds et al., Replacement Therapy in a Dry Mouth Patient: A Review, J. Hosp. Dent. Pract., 14, 30-34, (1980)
  • K. Hoerman et al., Gas Analysis of Saliva after Stimulation by Adipic Acid Slowly Released from Chewing Gum, J. Dent. Res., 64, 327, No. 1371, (1985), (Abstract Only)
  • K. C. Hoerman et al., Macromolecular Effects on the Titration Curves of Parotid Gland Fluid, J. Dent. Res., 47, 74-82, (1968)
  • G. N. Jenkins, "Salivary Effects on Plaque pH", 307-22, in I. Kleinberg et al., eds., Saliva and Dental Caries, (1979)
  • C. J. Kleber et al., Changes in Salivary pH after Ingestion of Sorbitol Tablets containing Various Food Acidulants, J. Dent. Res., 58, 1564-65, (1979)
  • R. J. Mathew et al., Xerostomia and Sialorrhea in Depression, Am. J. Psychiatry, 136, 1476-77, (1979)
  • J. R. McClelland, The Influence of Various Stimuli upon Human Saliva, Am. J. Physiol., 63, 127-41, (1922)
  • C. Nevin et al., Slow Release of Adipic Acid from Chewing Gum: Effects on Salivary Flow and Volume, J. Dent. Res., 64, 327, No. 1370, (1985), (Abstract Only)
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  • A. Spielman, Reply, Oral Surg., 52, 263, (1982
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