Drug delivery system

Patent 4904479 Issued on February 27, 1990. Estimated Expiration Date:

February 27, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3867521

Ophthalmic drug delivery system utilizing thermosetting gels
Patent #: 4474751
Issued on: 10/02/1984
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Drug delivery system utilizing thermosetting gels
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Inventor

Illum, Lisbeth

Assignee

Danbiosyst UK Limited

Application

No. 004189 filed on 01/15/1987

US Classes:

424/490, Coated (e.g., microcapsules)424/491, Containing proteins and derivatives424/493, Containing polysaccharides (e.g., sugars)424/496, Containing natural gums/resins424/497Containing solid synthetic polymers

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

Bachman & Lapointe

International Classes

A61K 009/14
A61K 045/08

Foreign Application Priority Data

1986-01-17 GB

Abstract

Particles of a drug are directed away from the reticuloendothelial system by the use of surface coating and surface grafting techniques which substantially prevent the take up of the composite particles by the liver.

Other References

"Effects of the Nonionic Surfactant Ploxamer 338 on the Fate and Deposition of Polystyrene Microspheres Following Intravenous Administration", by Lisbeth Illum and Stanley S. Davis Journal of Pharmaceutical Sciences, vol. 72, No. 9, Sep., 1983, pp. 1086-1089
"The Organ Uptake of Intravenously Administered Colloidal Particles can be Altered Using A Non-Ionic Surfactant (Poloxamer 338)", L. Illum and S. S. Davis, FEBS Lettersm, vol. 167, No. 1, Feb. 1984, pp. 79-82
"The Effect of Hydrophilic Coatings on the Uptake of Colloidal Particles by the Liver and by Peritoneal Macrophases", By L. Illum, I. M. Hunneyball and S. S. Davis, International Journal of Pharmaceuticals, vol. 29, 1986, pp. 53-65
Thesis: "Microspheres and Site Specific Delivery", Lisbeth illum, Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen, 1987
"The Organ Distribution and Circulation Time of Intravenously Injected Colloidal Carriers Sterically Stabilized with a Block Copolymer-Poloxamine 908", By L. Illum, S. S. Davis, R. H. Muller, E. Mak and P. West, Life Sciences, vol. 40, pp. 367-374, 1987
"Targeting of Colloidal Particles to the Bone Marrow", By L. Illum and S. S. Davis, Life Sciences, vol. 40, pp. 1553-1560, 198