Novel process for the synthesis of amikacin
February 20, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby Aminoglycoside antibiotic compounds Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides Patent #: 4468513 InventorsAssigneeApplicationNo. 914451 filed on 10/02/1986US Classes:536/13.7, Kanamycin or derivative536/13.8Carbonyl bonded directly to kanamycin nitrogenExaminersPrimary: Griffin, Ronald W.Assistant: Webber, Pamela S. Attorney, Agent or FirmInternational ClassesC07H 015/20C07H 015/22 Foreign Application Priority Data1985-10-10 ITAbstractA novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective. |
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