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Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents

Patent 4900746 Issued on February 13, 1990. Estimated Expiration Date: Icon_subject July 1, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 214698 filed on 07/01/1988

US Classes:

514/400, At imidazole ring carbon530/860, RENIN INHIBITORS548/338.1Having -C(=X)-, wherein X is chalcogen, bonded directly to the nitrogen

Examiners

Primary: Schwartz, Richard A.

Attorney, Agent or Firm

Foreign Patent References

  • 128762 EP. 12/13/1984
  • 172346 EP. 02/13/1986
  • 172347 EP. 02/13/1986
  • 181110 EP. 05/13/1986
  • 189203 EP. 07/13/1986
  • 200406 EP. 12/13/1986
  • 216539 EP. 04/13/1987
  • 229667 EP. 07/13/1987
  • 300189 EP. 01/13/1989
  • 307837 EP. 03/13/1989
  • 87/04349 WO. 07/13/1987

International Classes

A61K 031/415
C07D 233/64

Abstract

Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.

Other References

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