Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative
July 30, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSustained release pharmaceutical composition Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use Sustained release pharmaceutical composition of solid medical material Aspirin tablet Retard form of pharmaceuticals with insoluble porous diffusion coatings Controlled release dosage forms comprising hydroxypropylmethylcellulose Sustained release tablets made from microcapsules Patent #: 4710384 InventorsAssigneeApplicationNo. 079206 filed on 07/30/1987US Classes:424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/470, Where particles are granulated424/494, Cellulose derivatives424/497Containing solid synthetic polymersExaminersPrimary: Bell, Mark L.Assistant: Brunsman, David Attorney, Agent or FirmInternational ClassesA61K 009/16A61K 009/24 Foreign Application Priority Data1986-08-01 GBAbstractThe present invention provides a sustained release methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a predetermined dose or number of doses of Ibuprofen, each granule having a diameter between 0.5 and 2.0 mm and comprising:(a) a core containing 100 parts of Ibuprofen and from 10 to 70 parts of a microcrystalline cellulose; and(b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and 20 to 70 parts of a water-soluble hydroxylated cellulose derivative, the weight of the coating being from 5 to 20% of the weight of the core.Other References
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