Substituted pyranone inhibitors of cholesterol synthesis
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
Prodrugs of antihypercholesterolemic compounds
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof Patent #: 4739073
ApplicationNo. 151512 filed on 02/18/1988
US Classes:548/253, The chalcogen, X, is in a -C(=X)- group548/118The five-membered hetero ring contains at least three ring nitrogens
ExaminersPrimary: Springer, David B.
Attorney, Agent or Firm
Foreign Patent References
International ClassC07D 257/04
AbstractThis invention provides novel tetrazole intermediates of the formula ##STR1## wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl;R2,R3,R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy;B is hydrogen, C1-4 alkoxycarbonyl, CH2 Y or CH2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R10 is C1-4 alkyl; andR11 is phenyl which is unsubstituted or substituted by one or two C1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.