Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
February 18, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMevalonolactone derivatives Substituted pyranone inhibitors of cholesterol synthesis Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives Prodrugs of antihypercholesterolemic compounds Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof Patent #: 4739073 InventorsAssigneeApplicationNo. 151512 filed on 02/18/1988US Classes:548/253, The chalcogen, X, is in a -C(=X)- group548/118The five-membered hetero ring contains at least three ring nitrogensExaminersPrimary: Springer, David B.Attorney, Agent or FirmForeign Patent References
International ClassC07D 257/04AbstractThis invention provides novel tetrazole intermediates of the formula ##STR1## wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl;R2,R3,R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy;B is hydrogen, C1-4 alkoxycarbonyl, CH2 Y or CH2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R10 is C1-4 alkyl; andR11 is phenyl which is unsubstituted or substituted by one or two C1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.Other References
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