Process for preparing optically active indoline-2-carboxylic acid
Patent 4898822 Issued on February 6, 1990. Estimated Expiration Date: 
February 6, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 6, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesComposition and process for treating steel Patent #: 4486241 Inventors
AssigneeApplicationNo. 846436 filed on 03/31/1986US Classes:435/121, Nitrogen as only ring hetero atom435/136, Containing a carboxyl group435/170, Using bacteria435/180, Carrier is synthetic polymer435/197, Carboxylic ester hydrolase (3.1.1)435/280, Resolution of optical isomers or purification of organic compounds or composition containing same435/830, Arthrobacter435/839, Bacillus subtilis435/843, Corynebacterium435/874, Pseudomonas435/897, Streptomyces griseus435/911, Using fungi435/921, Candida435/925CephalosporiumExaminersPrimary: Warren, Charles F.Assistant: Marx, Irene Attorney, Agent or FirmInternational ClassesC12P 017/10C12P 001/04 C12N 009/18 C07P 041/00 Foreign Application Priority Data1985-04-01 JPAbstractA process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.Other References
Field of SearchCarrier is synthetic polymerResolution of optical isomers or purification of organic compounds or composition containing same Derived from bacteria Derived from fungi From yeast From aspergillus Carboxylic ester hydrolase (3.1.1) Triglyceride splitting (e.g., lipase, etc. (3.1.1.3)) Carboxylic acid ester Containing a carboxyl group Preparing heterocyclic carbon compound having only O, N, S, Se, or Te as ring hetero atoms Containing two or more hetero rings Containing at least two hetero rings bridged or fused among themselves or bridged or fused with a common carbocyclic ring system, (e.g., rifamycin, etc.) Using bacteria or actinomycetales Nitrogen or oxygen hetero atom and at least one other diverse hetero ring atom in the same ring Nitrogen as only ring hetero atom |
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