Controlled absorption diltiazem formulation for once-daily administration
November 16, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesEncapsulation of active agents as microdispersions in homogeneous natural polymeric matrices Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating Pharmaceutical sustained-release compositions Sustained-release vasodilator Aspirin tablet Drug delivery device Process for treating dosage forms New pharmaceutical forms for administration of medicaments by oral route, with programmed release Controlled release formulation Inhibition of tumor growth and metastasis with calcium channel blocker compounds InventorsAssigneeApplicationNo. 121225 filed on 11/16/1987US Classes:424/497, Containing solid synthetic polymers424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490Coated (e.g., microcapsules)ExaminersPrimary: Page, Thurman K.Assistant: Horne, Leon R. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/16AbstractA diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twenty four hour period following oral administration.Other References
Field of SearchOrganic coatingsContaining solid synthetic polymers Sustained or differential release type With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.) Coated (e.g., microcapsules) Containing solid synthetic polymers Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) | |
