Intra-pocket drug delivery devices for treatment of periodontal diseases
Patent 4892736 Issued on January 9, 1990. Estimated Expiration Date: June 3, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/435, Mouth424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/444, Resorbable by the body432/80Work manipulated in cooling zone
Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.
Other References
P. Fauchard, "The Surgeon Dentist, A Treatise on Teeth," 1746, 2nd ed. Translation by L. Lindsay, Butterworth & Co., London 1946
S. S. Socransky, J. Periodontol., 48, 497 (1977)
J. M. Goodson et al., J. Clin. Periodontal., 6, 83 (1979)
J. Lindhe et al., J. Clin. Periodontol., 6, 141 (1979)
R. J. Genco, J. Periodontol., 52, 545 (1981)
J. Lindhe et al., J. Clin. Periodontol., 9, 115 (1982)
J. M. Goodson et al., J. Dental Res., 57, 269 (1978) Abstract #766
A. Haffajee et al., J. Dental Res., 57, 269 (1978) Abstract #767
J. M. Goodson et al., J. Dental Res., 61, 274 (1982) Abstract #860
R. L. Dunn et al. J. Dental Res., 61, 274 (1982) Abstract #861
R. L. Dunn et al., J. Dental Res., 62, 289 (1983) Abstract #1084
R. L. Dunn et al., Controlled Release Society Meeting, Jul. 1982 CRS 82
Excerpts from "The Polymer Handbook" 2nd ed., J. Brandrup and E. H. Immergut, eds., John Wiley & Sons (1975)
Chem. Abstracts, 95, 86264k, "Anesthetic Effect of Local Anesthetics Grafted onto Poly(Vinyl Alcohol)-Based Polymer Fibers" by Khatskevich et al., Stomatologiya (Moscow), 60, 12-14 (1981)
Chem. Abstracts, 84, 95585r, "Oxytetracycline Formulation to be Applied at the Oral Mucosa", by J. Korbar-Smid et al., Acta Pharm. Jugosl., 25, 271-6 (1975)
R. P. Langer and N. Peppas, "Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: a Review", Rev. Macromol. Chem. Phys. 23, 61-126 (1983)
J. M. Goodson et al., "Monolithic Tetracycline-Containing Fibers for Controlled Delivery to Periodontal Pockets." J. Periodontol., 54, 575-579 (1983)
Computer Printouts of Patents Citing the Shepherd Patent 3,849,185
Computer Printouts of Patents Citing the Stephenson Patent 4,024,871
Computer Printout of a Search in the Patent Data Base for Patents Dealing Generally with the Subject Matter of this Application
J. M. Goodson Medical Applications of Controlled Release, vol. II, Chapter 7, CRC Press, Boca Raton, 115-138 (1984)*
M. A. Listgarten, J. Periodontol., 47, 1-18 (1976)*
L. Flotra et al., Scand. J. Dent. Res., 80, 10-17 (1972)