Diltiazem formulation
November 16, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled drug releasing preparations Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating Retard form of pharmaceuticals with insoluble porous diffusion coatings Compressed tablets for disintegration in the colon comprising an active ingredient containing nucleus coated with a first layer containing microcrystalline cellulose which is coated with an enteric organic polymer coating Pharmaceutical compositions and methods for producing alpha antagonism Pharmaceutical sustained-release compositions Aspirin tablet Drug delivery device Process for treating dosage forms InventorsAssigneeApplicationNo. 120952 filed on 11/16/1987US Classes:424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/459, Organic coatings424/462, Containing solid synthetic polymers424/470, Where particles are granulated424/493, Containing polysaccharides (e.g., sugars)424/494, Cellulose derivatives424/495, Ethyl cellulose424/497Containing solid synthetic polymersExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 009/62A61K 009/16 A61K 009/26 Foreign Application Priority Data1983-12-22 IEAbstractA diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of diltiazem from the pellet at a rate allowing controlled absorption thereof over a twelve hour period following oral administration. The pellet has a dissolution rate in vitro which when measured in a dissolution apparatus (Paddle) according to U.S. Pharmacopoeia XXI in 0.05 M KCl at pH 7.0 results in not more than 35% of the total diltiazem being released after 2 hours of measurement. Not more than 80% of the total diltiazem is released after six hours of measurement and not less than 85% of the total diltiazem is released after 13 hours of measurement.Other References
Field of SearchContaining polysaccharide (e.g., cellulose sugars, etc.)Containing solid synthetic polymers Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Coated pills or tablets Where particles are granulated Containing proteins or derivatives thereof Containing polysaccharide (e.g., sugar, etc.) Containing natural gums or resins Containing solid synthetic polymers Coated (e.g., microcapsules) Cellulose derivatives Containing polysaccharides (e.g., sugars) Ethyl cellulose Containing solid synthetic polymers | |
