Skin penetration enhancement using free base and acid addition salt combinations of active agents
Patent 4888354 Issued on December 19, 1989. Estimated Expiration Date: 
December 21, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 21, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3337628 3520919 Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone Propranolol hydrochloride liquid formulations Etofenamate formulation Patent #: 4731384 InventorsAssigneeApplicationNo. 136115 filed on 12/21/1987US Classes:514/424, Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding514/78, Lecithins514/272, Nitrogen bonded directly to the 1,3-diazine at 2-position514/289, Two of the cyclos share at least three ring members (i.e., bridged) (e.g., morphinans, etc.)514/343, The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.)514/357, Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding514/617, R contains benzene ring514/652, Alkanol group only between the amino nitrogen and an ether oxygen which is bonded directly to the aryl ring or aryl ring system (i.e., aryloxy alkanol amines)514/657, Bicyclo ring system514/661Polycyclo ring systemExaminersPrimary: Dixon, William R. Jr.Assistant: Medley, Margaret International ClassA01N 043/36AbstractThe invention is directed to compositions for topical application made up of active pharmaceutical permeants capable of existing in both free base and acid addition salt form. The permeants are present as a combination of both free base and acid addition salt forms. These combined forms provide skin penetration rates which are greater than the penetration rate of either the free base or acid addition salt forms utilized separately. The combined free base-acid addition salt permeants are formulated in a carrier vehicle which preferably also possesses skin penetration enhancement activity.Other References
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