U.S. patents available from 1976 to present.
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Steroid 5-alpha-reductase inhibitors

Patent 4888336 Issued on December 19, 1989. Estimated Expiration Date: Icon_subject July 28, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2897202

N-substituted-17ଲ-carbamoylandrost-4-en-3-one 5଱ reductase inhibitors
Patent #: 4191759
Issued on: 03/04/1980
Inventor: Johnston ,   et al.

Preparation of 4-aza-17-substituted-5଱-androstan-3-ones useful as 5଱-reductase inhibitors
Patent #: 4220775
Issued on: 09/02/1980
Inventor: Rasmusson ,   et al.

Novel steroid 5଱-reductase inhibitors
Patent #: 4317817
Issued on: 03/02/1982
Inventor: Blohm ,   et al.

4-Aza-17ଲ-substituted-5଱-androstan-3-one-reductase inhibitors
Patent #: 4377584
Issued on: 03/22/1983
Inventor: Rasmusson ,   et al.

Steroidic 5଱-reductase inhibitors
Patent #: 4732897
Issued on: 03/22/1988
Inventor: Cainelli ,   et al.

17ଲ-N-monosubstituted carbamoyl-4-aza-5଱-androst-1-en-3-ones which are active as testosterone 5଱-reductase inhibitors Patent #: 4760071
Issued on: 07/26/1988
Inventor: Rasmusson ,   et al.

Inventors

Application

No. 007539 filed on 07/28/1987

US Classes:

514/278, Spiro ring system514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos514/859, Acne546/16, The spiro includes the six-membered hetero ring546/77, The six-membered hetero ring shares ring members with one other cyclo only546/78Plural chalcogens bonded directly to carbocyclic rings of the tetracyclo ring system (e.g., pyridoanthraquinones, etc.)

Examiners

Primary: Shah, Mukund J.
Assistant: Rozycki, Andrew G.

Attorney, Agent or Firm

International Classes

A61K 031/58
C07J 073/00

Abstract

Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.

Other References

  • Singh et al., "Some U-Araspirostan Analogues", Indian J. Chem., vol. 11, pp. 1254-1256 (1973)
  • Singh et al., "Steroids and Related Studies", J. Chromatography, vol. 137, pp. 202-205 (1977)
  • Brooks et al., "Prostatic Effects . . . of 5଱-Reductase Inhibitors", The Prostate, 9:65-75 (1986)
  • Burger, Med. Chem. 2nd Ed., p. 42 (1960)
  • Singh et al. (I) Chem. Abs., vol. 87 entry 77955n (1977)
  • Singh et al. (II) Chem. Abs., vol. 80, entry 133690y (1974)
  • Liang, T. et al., J. Steroid Biochem. 19:385-90 (1983)
  • Blohm, T. R. et al., Biochem. Biophys. Res. Comm. 95:273-80 (1980
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