Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals
Patent 4886812 Issued on December 12, 1989. Estimated Expiration Date: 
October 12, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 12, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References4,5 or 6-Alkylaminoalkyl-2-alkyl-4,5,6,7-tetrahydro benzo[d]thiazoles Patent #: 4337343 Inventors
AssigneeApplicationNo. 256671 filed on 10/12/1988US Classes:514/321, Plural hetero atoms in the polycyclo ring system514/367, Bicyclo ring system having the thiazole ring as one of the cyclos540/603, Plural hetero atoms in the additional hetero ring544/135, Benzothiazoles (including hydrogenated)546/198, Ring nitrogen in the polycyclo ring system548/161, Nitrogen attached directly to the thiazole ring by nonionic bonding548/163, Carbonyl or thiocarbonyl bonded directly to the nitrogen548/164The nitrogen bonded additionally only to hydrogenExaminersPrimary: Gerstl, RobertAttorney, Agent or FirmForeign Patent References
International ClassesC07D 277/82A01K 031/425 Foreign Application Priority Data1984-12-22 DEAbstractThis invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms,R2 represents a hydrogen atom or an alkyl group,R3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms,R4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR3 and R4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R1 or R3 or both groups R1 and R3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.Field of SearchNitrogen attached directly to the thiazole ring by nonionic bondingCarbonyl or thiocarbonyl bonded directly to the nitrogen The nitrogen bonded additionally only to hydrogen Ring nitrogen in the polycyclo ring system Plural hetero atoms in the additional hetero ring Benzothiazoles (including hydrogenated) Plural hetero atoms in the polycyclo ring system Bicyclo ring system having the thiazole ring as one of the cyclos |
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