Liquid chromatograph/mass spectrometer interface
Methods and apparatus for mass spectrometric analysis of constituents in liquids
Electrophoresis-mass spectrometry probe Patent #: 4705616
ApplicationNo. 178046 filed on 04/05/1988
US Classes:204/451, Capillary electrophoresis204/601, Capillary electrophoresis type250/288With sample supply means
ExaminersPrimary: Niebling, John F.
Assistant: Rodriguez, Isabelle
Attorney, Agent or Firm
International ClassB01D 059/44
AbstractA system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., b1;2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.
Field of SearchWith sample supply means