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US Patent 4883785 - Complex of anti-fungal agent and cyclodextrin and method
US Patent Issued on November 28, 1989
Estimated Patent Expiration Date:
November 28, 2006Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
November 28, 2006Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractAn anti-fungal complex formed of a polyene anti-fungal agent, such as amphotericin B, and cyclodextrin, preferably γ-cyclodextrin, is provided. The complex which includes amphoterin B has improved water solutility and stability over prior art amphotericin B anti-fungal agents. A method for forming the complex is also provided wherein anti-fungal agent, such as amphoterin B, is dissolved in an aqueous solution of cyclodextrin of pH ranging from about 9 to about 12 and the resulting solution is maintained at a pH ranging from about 6 to about 8 to form the subject complex. The solution can be lyophilized as desired to achieve higher solubility.Other References
| InventorsApplicationNo. 635030 filed on 07/27/1984US Classes:514/31, The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.)514/58, Dextrin or derivative536/6.5, Oxygen containing hetero ring having at least twenty members (e.g., amphotericin, nystatin, pimaricin, etc.)536/46, Dextrin derivatives536/112Dextran or derivativeField of Search536/6.5, Oxygen containing hetero ring having at least twenty members (e.g., amphotericin, nystatin, pimaricin, etc.)536/46, Dextrin derivatives536/112, Dextran or derivative514/31, The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.)514/58Dextrin or derivativeExaminersPrimary: Brown, Johnnie R.Assistant: Peselev, Elli Attorney, Agent or FirmUS Patent References4383992, Water-soluble steroid compoundsIssued on: 05/17/1983 Inventor: Lipari4423040, Vehicle composition containing 1-substituted azacyclohexan-2-ones Issued on: 12/27/1983 Inventor: Rajadhyaksha4438106, Inclusion compound of eicosapentaenoic acid or docosahexaenoic acid with cyclodextrin Issued on: 03/20/1984 Inventor: Wagu , et al.4482709, Inclusion compounds of cyclodextrin with sulfur-containing compounds Issued on: 11/13/1984 Inventor: Iwao , et al.4497803Inclusion compound of lankacidin-group antibiotic and use thereof Issued on: 02/05/1985 Inventor: Harada , et al. Foreign Patent References
International ClassesA61K 031/70C07H 017/08 |
