Complex of anti-fungal agent and cyclodextrin and method
Patent 4883785 Issued on November 28, 1989. Estimated Expiration Date: 
November 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesWater-soluble steroid compounds Vehicle composition containing 1-substituted azacyclohexan-2-ones Inclusion compound of eicosapentaenoic acid or docosahexaenoic acid with cyclodextrin Inclusion compounds of cyclodextrin with sulfur-containing compounds Inclusion compound of lankacidin-group antibiotic and use thereof Patent #: 4497803 InventorsApplicationNo. 635030 filed on 07/27/1984US Classes:514/31, The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.)514/58, Dextrin or derivative536/6.5, Oxygen containing hetero ring having at least twenty members (e.g., amphotericin, nystatin, pimaricin, etc.)536/46, Dextrin derivatives536/112Dextran or derivativeExaminersPrimary: Brown, Johnnie R.Assistant: Peselev, Elli Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/70C07H 017/08 AbstractAn anti-fungal complex formed of a polyene anti-fungal agent, such as amphotericin B, and cyclodextrin, preferably γ-cyclodextrin, is provided. The complex which includes amphoterin B has improved water solutility and stability over prior art amphotericin B anti-fungal agents. A method for forming the complex is also provided wherein anti-fungal agent, such as amphoterin B, is dissolved in an aqueous solution of cyclodextrin of pH ranging from about 9 to about 12 and the resulting solution is maintained at a pH ranging from about 6 to about 8 to form the subject complex. The solution can be lyophilized as desired to achieve higher solubility.Other References
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