Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase
Patent 4882319 Issued on November 21, 1989. Estimated Expiration Date: 
December 23, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 23, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsApplicationNo. 290056 filed on 12/23/1988US Classes:514/119, C(=O)N containing514/75, Phosphorus containing other than solely as part of an inorganic ion in an addition salt DOAI514/79, Nitrogen containing hetero ring514/85, Hetero ring is six-membered consisting of two nitrogens and four carbons514/86, Nitrogen atoms occupy 1 and 3- positions514/90, Chalcogen in the six-membered hetero ring514/91, Hetero ring is five-membered514/92, Two or more hetero atoms in the five-membered ring514/100, Polycyclo ring system having the hetero ring as one of the cyclos514/113, Cyano or isocyano bonded directly to a benzene ring514/125, Ketone or aldehyde containing514/130, The oxygen is bonded directly to a benzene ring514/141, (CX-) (C)P=X(XH) or (CX-) (R)P=X(XC) containing (e.g., phosphonate, etc.) (X is chalcogen; R is C or H)540/23, The spiro atom is the 17-position carbon of the cyclopentanohydrophenanthrene ring system540/95, The hetero ring contains nitrogen540/100The hetero ring contains plural chalcogensExaminersPrimary: Robinson, Douglas W.Assistant: Lipovsky, Joseph A. Attorney, Agent or FirmInternational ClassesA61K 031/66A61K 031/665 A61K 031/675 C07J 001/00 AbstractInvented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.Other References
Field of SearchThe spiro atom is the 17-position carbon of the cyclopentanohydrophenanthrene ring systemThe hetero ring contains nitrogen The hetero ring contains plural chalcogens The chalcogen is bonded directly at the 17-position of the cyclopentanohydrophenanthrene ring system Phosphorus containing other than solely as part of an inorganic ion in an addition salt DOAI Nitrogen containing hetero ring Hetero ring is six-membered consisting of two nitrogens and four carbons Nitrogen atoms occupy 1 and 3- positions Chalcogen in the six-membered hetero ring Hetero ring is five-membered Two or more hetero atoms in the five-membered ring Polycyclo ring system having the hetero ring as one of the cyclos Cyano or isocyano bonded directly to a benzene ring Ketone or aldehyde containing The oxygen is bonded directly to a benzene ring (CX-) (C)P=X(XH) or (CX-) (R)P=X(XC) containing (e.g., phosphonate, etc.) (X is chalcogen; R is C or H) |
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