Prevention of fescue toxicosis
Patent 4880632 Issued on November 14, 1989. Estimated Expiration Date: 
September 8, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 8, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of controlling emesis caused by cisplatin in cancer chemotherapy Method for percutaneously administering metoclopramide Prolonged release microcapsules and their production Methods of treating and preventing tall fescue toxicosis by the administration of thiamin Patent #: 4755519 InventorsAssigneeApplicationNo. 093951 filed on 09/08/1987US Classes:424/425, Diffusion barrier is matrix424/422, Implant or insert424/442, Animal food424/486, Synthetic polymer514/617, R contains benzene ring514/619Nitrogen in RExaminersPrimary: Schofer, Joseph L.Assistant: Curtis, Pili Attorney, Agent or FirmInternational ClassesA61K 009/26A61K 031/165 AbstractA method, and compositions, for use in the prevention and treatment of fescue toxicosis in animals, especially cattle, sheep and horses, comprising administering to the animals a dopamine antagonist which does not cause adverse psychological or neurological effects. Useful dopamine antagonists are those specific for D2 receptors including metoclopramide, sulpiride, tiapride, alizapride and other substituted benzamides. The preferred compound is metoclopramide, a substituted benzamide having the formula 4-amino-5 chloro-N-[2-(diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate. The correct dosage can be determined from the combination of the behavioral response of the animal to the compound and by measuring the serum prolactin levels over time.In the preferred method, the compound is administered to the animals orally, using capsules, timed or slow release boluses, or as an additive in a salt, mineral, protein or energy block or animal feed, or as an implant.Other References
Field of SearchAnimal foodSurgical implant or material Implant or insert Diffusion barrier is matrix Synthetic polymer Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments Nitrogen in R Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding | |
