Aqueous nitroglycerin injection and manufacturing process
Patent 4879308 Issued on November 7, 1989. Estimated Expiration Date: 
August 11, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 11, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPercutaneous administration of nitroglycerine Aqueous solution of nitroglycerin Water-soluble composition for forming an aqueous isotonic nitroglycerine solution and the nitroglycerine solution formed Organic nitrate drug mixtures resistant to detonation by fire Patent #: 4746506 InventorsAssigneeApplicationNo. 084631 filed on 08/11/1987US Classes:514/509, (O=)N(=O)-O-C containing (e.g., nitrate ester, etc.)514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENTExaminersPrimary: Howard, Jacqueline V.Attorney, Agent or FirmForeign Patent References
International ClassA61K 031/21AbstractNitroglycerin injection that is free of the customary organic solvents and has an extended shelf life of at least 1 year, consisting essentially of water, lactose, and nitroglycerin. Sodium chloride or dextrose may be added during manufacture or upon diluting with an infusion. Commerically safe manufacture and stable dispersion are assured by mixing lactose adsorbate, containing nitroglycerin, with water at high shear so that no nitroglycerin droplets coalesce. Stability is maintained by filtering and filling operations using nonreactive, nonleaching, nonadsorptive materials.Other References
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