U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Novel dibenzothiazepine antipsychotic

Patent 4879288 Issued on November 7, 1989. Estimated Expiration Date: Icon_subject March 20, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3325497

3389139

3459745

3539573

3723466

3755340

3761481

3928356

Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
Patent #: 3962248
Issued on: 06/08/1976
Inventor: Schneider

Dibenzodiazepines
Patent #: 4096261
Issued on: 06/20/1978
Inventor: Horrom ,   et al.

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Inventors

Assignee

Application

No. 028473 filed on 03/20/1987

US Classes:

514/211.13, Nitrogen bonded directly to ring carbon of the seven-membered hetero ring540/551Nitrogen bonded directly to ring carbon of the hetero ring

Examiners

Primary: Berch, Mark L.

Attorney, Agent or Firm

Foreign Patent References

  • 721822 BE. 04/13/1969
  • 1620188 DE. 04/13/1970

International Classes

C07D 417/04
A61K 031/555

Foreign Application Priority Data

1986-03-27 GB

Abstract

11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia.

Other References

  • Chemical Abstracts, vol. 93, No. 11, 15th Sep. 1980, p. 727, col. 1, abstract No. 114451y, Columbus, OH, US; abstract of: "Piperazinyldibenzazepine", RES. DISCL. 1980, 192, 158-159
  • "Piperazinyldibenzazepine", RES. DISCL. 1980, 192, 158-159
  • Tobler, E. and Foster, D. J. Helv. Chim. Acta., 48:336 (1965)
  • Ther, L. and Schramm, H. Arch. Int. Pharmacodyn., 138:302 (1962)
  • Puech, A. J., Simon, P. and Boissier, J., Eur. J. Pharm., 50:291 (1978)
  • Swerdlow, U. R. and Koob, G. F., Pharmacol. Biochem. and Behav., 23:303 (1985)
  • Carlson, A. and Lindquist, M., Acta. Pharmac. Tox., (1963) 20:140
  • Saller, L. F. and Salama, A. I., J. Chromatography, (1984) 309:287
  • Herz, A., Int. Rev. Neurobiol., (1960) 2:229-277
  • Barany, S., Haggstrom, J. H. and Gunne, L. M., Acta. Pharmacol. et. Toxicol., (1983) 52:86
  • Liebman, J. and Neale, R., Psychopharmacology (1980), 68:25-29
  • Weiss, B. and Santelli, S., Science, (1978), 200:799-801
  • Gunne, A. and Barany, S., Psychopharmacology, (1979), 63:195-19
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