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US Patent 4879286 - Cyclophosphamide
US Patent Issued on November 7, 1989
Estimated Patent Expiration Date:
April 4, 2008Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
April 4, 2008Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractA storage-stable liquid oncolytic formulation of cyclophosphamide for parenteral administration is presented. Currently utilized lyophilized formulations have inherent diseconomies and increased hazard is associated with reconstitution. The liquid formulations of the present invention comprise a solution of cyclophosphamide with an organic polyol as cosolvent, which provide enhanced shelf-life and greater ease of administration. The polyol is either propylene glycol, polyethylene glycol or glyerol. The solution of cyclophosphamide is either aqueous, or in the case of propylene glycol may constitute 10-30% by weight of an alcohol. | InventorsAssigneeApplicationNo. 178761 filed on 04/04/1988US Classes:514/110Phosphorus is part of a ringField of Search514/110Phosphorus is part of a ringExaminersPrimary: Goldberg, Jerome D.Attorney, Agent or FirmUS Patent References3018302, 3732340, 4537883Lyophilized cyclophosphamideIssued on: 08/27/1985 Inventor: Alexander , et al. Foreign Patent References
International ClassA61K 031/66 |
