Electrolytic transdermal delivery of polypeptides

Patent 4878892 Issued on November 7, 1989. Estimated Expiration Date:

February 10, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Drug Delivery Systems Inc.

Application

No. 012889 filed on 02/10/1987

US Classes:

604/20Infrared, visible light, ultraviolet, X-ray or electrical energy applied to body (e.g., iontophoresis, etc.)

Examiners

Primary: Rosenbaum, C. Fred
Assistant: Polutta, Mark O.

Attorney, Agent or Firm

Lackenbach, Siegel Marzullo & Aronson

Foreign Patent References

0252732 EP 01/13/1988

International Class

A61N 001/30

Abstract

The invention comprises in combination:(a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and(b) an electrolytic device for transdermal transport of the polypeptide to the bloodstrem of the patient.It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants.The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patient's skin.Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.