U.S. patents available from 1976 to present.
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Compositions and method comprising heterocyclic compounds containing two heteroatoms

Patent 4876249 Issued on October 24, 1989. Estimated Expiration Date: Icon_subject January 12, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Topical anti-inflammatory drug therapy
Patent #: 4282216
Issued on: 08/04/1981
Inventor: Rovee ,   et al.

Topical anti-inflammatory drug therapy Patent #: 4473565
Issued on: 09/25/1984
Inventor: Rovee ,   et al.

Inventor

Application

No. 002387 filed on 01/12/1987

US Classes:

514/174-O-C-O- is part of a hetero ring (e.g., acetonide, etc.)

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 031/58

Abstract

A method and compositions for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or to the skin of humans and animals for localized use comprising applying to such skin or membrane a mixture of said physiologically active agent and a non-toxic, effective penetrating amount of penetration enhancing compound having the structural formula I: ##STR1## wherein: R is a saturated or unsaturated hydrocarbon group with from 5 to 19 carbon atoms; R' and R" are hydrogen, lower alkyl, trifluoromethyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl, with the proviso that both R' and R" are not lower hydroxyalkyl; X is O or NR1 ; R1 being hydrogen, lower alkyl, lower alkenyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl are disclosed.

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