Patent ReferencesTopical anti-inflammatory drug therapy Topical anti-inflammatory drug therapy Patent #: 4473565 InventorApplicationNo. 002387 filed on 01/12/1987US Classes:514/174-O-C-O- is part of a hetero ring (e.g., acetonide, etc.)ExaminersPrimary: Friedman, Stanley J.Attorney, Agent or FirmInternational ClassA61K 031/58AbstractA method and compositions for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or to the skin of humans and animals for localized use comprising applying to such skin or membrane a mixture of said physiologically active agent and a non-toxic, effective penetrating amount of penetration enhancing compound having the structural formula I: ##STR1## wherein: R is a saturated or unsaturated hydrocarbon group with from 5 to 19 carbon atoms; R' and R" are hydrogen, lower alkyl, trifluoromethyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl, with the proviso that both R' and R" are not lower hydroxyalkyl; X is O or NR1 ; R1 being hydrogen, lower alkyl, lower alkenyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl are disclosed.Field of Search-O-C-O- is part of a hetero ring (e.g., acetonide, etc.) | |