2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics
Patent 4873241 Issued on October 10, 1989. Estimated Expiration Date: 
October 31, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 31, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3408389 3923813 3923815 3923887 Dilignols and dilignol-type compounds Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines Patent #: 4602035 InventorsAssigneeApplicationNo. 265087 filed on 10/31/1988US Classes:514/237.8, Nitrogen attached indirectly to the morpholine ring by acyclic nonionic bonding514/319, The additional ring is one of the cyclos in a polycyclo ring system514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/428, Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding514/624, Three-membered ring in R514/626, Nitrogen in R544/165, Carbocyclic ring bonded directly to the nitrogen546/205, The polycyclo ring system is bicyclo-carbocyclic548/537, Acyclic nitrogen bonded directly to the -C(=X)- (e.g., 4,5-dihalopyrrole -2 carboxamides, etc.)548/568, Hydrogen or acyclic carbon bonded directly to the -C(=X)- (e.g., 2 pyrrolidine acrylamide, etc.)564/190, Three-membered ring in substituent Q564/194, Benzene ring in a substituent E564/308Polycyclo ring systemExaminersPrimary: Schwartz, Richard A.Assistant: Magrab, E. Brendan Attorney, Agent or FirmForeign Patent References
International ClassesC07D 295/14A61K 031/535 Abstract2-Amino-N-(2-phenylindan-2-yl)acetamides of the following formula are provided ##STR1## wherein, a=0 to 3,R1, R2 and R3 are independently selected from hydrogen and methyl,R4 is hydrogen or C1 -C4 alkyl,R5 is selected from hydrogen, C1 -C4 alkyl, cyclopropyl and (aminomethyl)carbonyl, orR4 and R5 taken together with the nitrogen atom to which they are attached from a heterocyclic ring selected from pyrrolidinyl, piperidinyl and morpholinyl, orR3 and R4 taken together with the carbon atom and nitrogen atom to which they are respectively attached form a heterocyclic ring selected from pyrrolidinyl and piperidinyl, andR6 is selected from hydrogen, halogen, C1 -C4 alkoxy, trifluoromethyl, C1 -C4 alkyl and combinations thereof.The compounds have antiepileptic or antihypoxia activity.Other References
Field of SearchThree-membered ring in substituent QBenzene ring in a substituent E Benzene ring containing Hydrogen or acyclic carbon bonded directly to the -C(=X)- (e.g., 2 pyrrolidine acrylamide, etc.) Acyclic nitrogen bonded directly to the -C(=X)- (e.g., 4,5-dihalopyrrole -2 carboxamides, etc.) The polycyclo ring system is bicyclo-carbocyclic Carbocyclic ring bonded directly to the nitrogen Nitrogen attached directly or indirectly to the hetero ring by acyclic nonionic bonding Benzene ring bonded directly to the hetero ring Nitrogen attached indirectly to the morpholine ring by acyclic nonionic bonding The additional ring is one of the cyclos in a polycyclo ring system C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen) Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding Benzene ring containing Three-membered ring in R Nitrogen in R |
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