Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof

Patent 4871716 Issued on October 3, 1989. Estimated Expiration Date:

December 3, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Metal containing polymeric functional microspheres
Patent #: 4157323
Issued on: 06/05/1979
Inventor: Yen , et al.

Magnetically responsive composite microparticle
Patent #: 4169804
Issued on: 10/02/1979
Inventor: Yapel, Jr.

Microspheres for incorporation of therapeutic substances and methods of preparation thereof
Patent #: 4671954
Issued on: 06/09/1987
Inventor: Goldberg , et al.

Magnetic particles for use in separations Patent #: 4695393
Issued on: 09/22/1987
Inventor: Chagnon , et al.

Inventors

Assignee

University of Florida

Application

No. 06/937611 filed on 12/03/1986

US Classes:

424/9.322, Polymer containing (e.g., polypeptide, synthetic resin, etc.)106/139.1, Cellulose ester or salt thereof252/62.51R, MAGNETIC252/62.55, Free metal or alloy containing424/491, Containing proteins and derivatives424/497, Containing solid synthetic polymers424/499, Contains proteins or derivative or polysaccharides or derivative424/501, Contains solid synthetic resin424/9.323, Metal is paramagnetic435/177, Enzyme or microbial cell is immobilized on or in an organic carrier436/173, NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY436/526, Magnetic436/528, Carrier is organic436/531, Carrier is synthetic resin436/829, LIPOSOMES (E.G., ENCAPSULATION, ETC.)514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/6, Heavy metal containing (e.g., hemoglobin, etc.)524/21, Animal derived protein or polypeptide other than casein, e.g., blood, egg albumin, etc.930/290, Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units977/788, Of specified organic or carbon-based composition977/838Magnetic property of nanomaterial

Examiners

Primary: Nucker, Christine M.

Attorney, Agent or Firm

Clarke; Dennis P.

International Classes

A61K 9/16 (20060101)
A61K 9/51 (20060101)

Abstract

Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically responsive material in an organic solvent solution of a high molecular weight polymer to form a stabilized dispersion of microspheres and cross-linking said microspheres with a polyfunctional cross-linking agent.