Recombinant baculovirus occlusion bodies in vaccines and biological insecticides

Patent 4870023 Issued on September 26, 1989. Estimated Expiration Date:

February 8, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Process for preparing chocolate chip cookies containing low melting fat and product
Patent #: 4722849
Issued on: 02/02/1988
Inventor: Dartey , et al.

Method for producing a recombinant baculovirus expression vector Patent #: 4745051
Issued on: 05/17/1988
Inventor: Smith , et al.

Inventors

Assignee

American Biogenetic Sciences, Inc.

Application

No. 07/153736 filed on 02/08/1988

US Classes:

435/235.1, VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATING435/243, MICRO-ORGANISM, PER SE (E.G., PROTOZOA, ETC.); COMPOSITIONS THEREOF; PROCES OF PROPAGATING, MAINTAINING OR PRESERVING MICRO-ORGANISMS OR COMPOSITIONS THEREOF; PROCESS OF PREPARING OR ISOLATING A COMPOSITION CONTAINING A MICRO-ORGANISM; CULTURE MEDIA THEREFOR435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/69.3, Antigens435/69.7, Fusion proteins or polypeptides530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/820, PROTEINS FROM MICRO-ORGANISMS530/826, Viruses536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/23.4, Encodes a fusion protein930/10, PEPTIDE OR PROTEIN SEQUENCE930/220Viral peptide or viral protein (See note 6)

Examiners

Primary: Wiseman, Thomas G.
Assistant: Seidman, Stephanie

Attorney, Agent or Firm

Pennie & Edmonds

International Classes

C12N 15/62 (20060101)
C12N 15/866 (20060101)
C07K 14/005 (20060101)
C07K 14/01 (20060101)
C07K 14/11 (20060101)
A61K 39/00 (20060101)

Abstract

The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant baculoviruses of the invention are formed by insertion into or replacement of regions of the polyhedrin gene that are not essential for occlusion body formation, with foreign DNA fragments by recombinant DNA techniques. The recombinant occlusion bodies produced in accordance with the present invention have uses in vaccine formulations, immunoassays, immobilized enzyme reactions, as biological insecticides, and as expression vectors.

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