Spheroids
Patent 4867985 Issued on September 19, 1989. Estimated Expiration Date: 
March 1, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 1, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesRapid releasing triamterene containing gelatin capsule dosage forms for once daily antihypertensive use Patent #: 4681765 InventorsAssigneeApplicationNo. 07/162640 filed on 03/01/1988US Classes:424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/458, Containing discrete coated particles pellets, granules, or beads424/459, Organic coatings424/488, Polysaccharides (e.g., cellulose, etc.)424/494Cellulose derivativesExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmInternational ClassA61K 9/16 (20060101)Foreign Application Priority Data1987-03-04 GBAbstractA controlled release pharmaceutical composition contains a number of spheroids, the spheroids containing a water-insoluble drug dispersed in a controlled release matrix. The matrix contains between 70% and 99.5% (by weight) of microcrystalline cellulose, between 0.5% and 4% (by weight) of a cellulose derivative and, optionally, up to 26% of a sugar or a sugar alcohol.The water insoluble drug must dissolve in water (pH 5) at 20° C. to a concentration of less than 1.0 mg ml-1, preferably less than 0.5 mg ml-1. Preferred drugs are non-steroidal anti-inflammatory agents, especially fenprofen calcium, ibuprofen, ketoprofen, naproxen, diclofenac sodium, fenbufen, flurbiprofen, indomethancin, oxyphenbutazone, phenylbutazone or piroxicam.Field of SearchPolysaccharides (e.g., cellulose, etc.)Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Containing discrete coated particles pellets, granules, or beads Discrete particles in supporting matrix Contains proteins or derivative or polysaccharides or derivative Sustained or differential release type Where particles are granulated Organic coatings Containing polysaccharide (e.g., cellulose sugars, etc.) Cellulose derivatives | |
