Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
July 13, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDosage for coadministering drug and percutaneous absorption enhancer Soft tertiary amine esters of bio-affecting carboxylic acids Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone Penetrating topical pharmaceutical compositions containing corticosteroids Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one Transdermal administration of fentanyl and device therefor Base composition for external preparations, pharmaceutical composition for external use and method of promoting percutaneous drug absorption Transdermal drug delivery device with dual permeation enhancers Patent #: 4764379 InventorsAssigneeApplicationNo. 07/218702 filed on 07/13/1988US Classes:514/784, Carboxylic acid or salt thereof514/772, DESIGNATED ORGANIC NONACTIVE INGREDIENT CONTAINING OTHER THAN HYDROCARBON514/785, Carboxylic acid ester514/786, Glyceride514/947Topical applicationExaminersPrimary: Terapane, John F.Assistant: Scalzo, Catherine S. Kilby Attorney, Agent or FirmInternational ClassesA61K 47/12 (20060101)A61K 47/10 (20060101) A61K 47/14 (20060101) AbstractPenetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-75% w., and preferably 5-49% w., of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof and (iii) 0-45% w., and preferably 1-45% w., of an inert diluent which, according to properties of the permeant used, may range from hydrophilic to hydrophobic. Water, polyethylene or polypropylene glycols and mineral oil are exemplary diluents.Other References
| |
