Biodegradable polymeric drug delivery system with adjuvant activity
October 2, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3773737 Biological materials Synthetic adjuvants for stimulation of antigenic responses Reactive alpha amino acid polymer Pharmaceutical compositions Biodegradable, implantable drug delivery depots, and method for preparing and using the same 3-Nitrobenzene sulfonanilide derivatives and fungicidal compositions for the control of plant diseases containing same Stimulation of chemotaxis by chemotactic peptides Biodegradable polypeptide and its use for the gradual release of drugs Granular dietetic product based on amino acids and process for their preparation Patent #: 4753804 InventorsApplicationNo. 06/914380 filed on 10/02/1986US Classes:424/422, Implant or insert424/280.1, Synthetic polymer or copolymer424/426, Errodable, resorbable, or dissolving424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/460, Containing proteins or derivatives thereof (e.g., gelatin, etc.)424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/23, Carbohydrate (i.e., saccharide radical containing) DOAI514/8, Glycoprotein (carbohydrate containing)514/885, IMMUNE RESPONSE AFFECTING DRUG514/953, SHAPED FORMS ADAPTED FOR NONINGESTIBLE USE OTHER THAN SUPPOSITORY TYPE (E.G., FILMS, INSERTS, ETC.)514/963, Microcapsule-sustained or differential release514/964, SUSTAINED OR DIFFERENTIAL RELEASE TYPE514/965, Discrete particles in supporting matrix525/54.1Containing chemically combined protein or biologically active polypeptideExaminersPrimary: Moskowitz, MargaretAssistant: Draper, Garnette D. Attorney, Agent or FirmInternational ClassesA61K 39/39 (20060101)A61K 47/48 (20060101) C08G 69/10 (20060101) C08G 69/00 (20060101) AbstractAn antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In one embodiment, the polymer is formed from tyrosine dipeptides. Poly(CTTH-iminocarbonate) is a preferred tyrosine dipeptide polymer for constructing implantable delivery systems for antigenic material. The polymer is not an adjuvant in itself but degrades into products which stimulate the immune system. The tyrosine dipeptide can also be used as a conventional adjuvant. The advantages of the system are that a polymer can be used to form a biodegradable integral structure which is useful as both an implantable source of an antigen or other biologically active compound and as a control means for the rate of release of the biologically active compound, wherein the result is sustained, relatively constant delivery of antigen with simultaneous stimulation of the immune response.Other References
| |
