17 -Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
Patent 4859681 Issued on August 22, 1989. Estimated Expiration Date: 
December 3, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 3, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2227876 3239417 3264301 3285918 Preparation of 4-aza-17-substituted-5-androstan-3-ones useful as 5-reductase inhibitors 4-Aza-17ଲ-substituted-5-androstan-3-one-reductase inhibitors 17ଲ-N-monosubstituted carbamoyl-4-aza-5-androst-1-en-3-ones which are active as testosterone 5-reductase inhibitors Patent #: 4760071 InventorsAssigneeApplicationNo. 07/129335 filed on 12/03/1987US Classes:514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos514/859, Acne546/77The six-membered hetero ring shares ring members with one other cyclo onlyExaminersPrimary: Sutto, Anton H.Assistant: Rivers, Diana G. Attorney, Agent or FirmInternational ClassesC07J 73/00 (20060101)C07C 62/00 (20060101) C07C 62/38 (20060101) Abstract17ଲ-Acyl-4-aza-5-androst-1-en-3-ones of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl andR2 is a monovalent radical selected from straight carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents, aralkyl selected from benzyl and phenethyl and heterocyclic selected from 2- or 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl;and R', R" and R'" are each selected from hydrogen and methyl and pharmaceutical formulation of the above compounds are active as testosterone 5-reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.Other References
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