Novel receptors for efficient determination of ligands and their antagonists or agonists

Patent 4859609 Issued on August 22, 1989. Estimated Expiration Date:

August 22, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Antibody steric hindrance immunoassay with two antibodies
Patent #: 3935074
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Inventors

Application

No. 06/857899 filed on 04/30/1986

US Classes:

436/501, BIOSPECIFIC LIGAND BINDING ASSAY435/7.22, Parasite or protozoa435/7.31, Fungi (e.g., yeast, mold, etc.)435/7.9, Assay in which an enzyme present is a label435/968, HIGH ENERGY SUBSTRATES (E.G., FLUORESCENT, CHEMILUMINESCENT, RADIOACTIVE, ETC.)436/503, Utilizing isolate of tissue or organ as binding agent436/537, Signal modification or steric inhibition436/63, BIOLOGICAL CELLULAR MATERIAL TESTED530/402, Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.530/806, ANTIGENIC PEPTIDES OR PROTEINS530/808MATERIALS AND PRODUCTS RELATED TO GENETIC ENGINEERING OR HYBRID OR FUSED CELL TECHNOLOGY, E.G., HYBRIDOMA, MONOCLONAL PRODUCTS, ETC.

Examiners

Primary: Warden, Robert J.
Assistant: Wagner, Richard

Attorney, Agent or Firm

Hensley; Max D.

International Classes

C07K 14/435 (20060101)
C07K 14/72 (20060101)
C07K 14/71 (20060101)
C07K 14/705 (20060101)
G01N 33/566 (20060101)
G01N 33/532 (20060101)
G01N 33/68 (20060101)

Abstract

Hybrid receptors are provided that comprise (a) the ligand binding domain of a predetermined receptor and (b) a heterologous reporter polypeptide. The hybrid receptors are useful for convenient and large scale assay of biologically active ligands or their antagonists or agonists.

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