Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof
Patent 4851426 Issued on July 25, 1989. Estimated Expiration Date: 
July 25, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 25, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3412131 3646201 Mannich-base hydroxamic acid prodrugs, compositions and use [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa Antifibrinolytically active derivatives of tranexamic acid Prodrug esters of diflunisal and related compounds Patent #: 4542158 InventorsApplicationNo. 06/810393 filed on 02/12/1986US Classes:514/420, Indomethacine per se or ester thereof514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/512, X-C(=X)-X containing (e.g., carbonic acid ester, thiocarbonic acid ester, etc.) (X is chalcogen)548/500, Having -C(=X)-, wherein X is chalcogen, bonded directly to ring nitrogen of the five-membered hetero ring (e.g., indomethacin, etc.)548/539, Carbocyclic ring bonded directly to the -C(=X)- (e.g., 3-benzoyl pyrrolidine, etc.)558/275, Benzene ring attached indirectly to the -O-C(=O)O- group by nonionic bonding558/276Nitrogen or chalcogen attached indirectly to the -O-C(=O)O- group by acyclic nonionic bondingExaminersPrimary: Springer, David B.Attorney, Agent or FirmInternational ClassesC07C 229/00 (20060101)C07C 229/38 (20060101) C07C 229/58 (20060101) C07D 207/337 (20060101) C07D 209/00 (20060101) C07D 207/00 (20060101) C07D 209/28 (20060101) C07D 209/26 (20060101) A61K 31/22 (20060101) A61K 31/21 (20060101) C07C 69/00 (20060101) C07C 69/96 (20060101) Foreign Application Priority Data1982-12-09 ILAbstractNovel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters. |
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