Hydroxylated 26-homo vitamin D derivatives and methods for preparing same
Patent 4851400 Issued on July 25, 1989. Estimated Expiration Date: 
July 25, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 25, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for preparing 1--hydroxy cholesterol derivatives Synthesis of steroids Synthesis of 1,25-dihydroxyergocalciferol Sidechain homo-vitamin D compounds with preferential anti-cancer activity Patent #: 4717721 InventorsAssigneeApplicationNo. 06/835711 filed on 03/03/1986US Classes:514/167, 9,10-seco- cyclopentanohydrophenanthrene ring system (e.g., vitamin D, etc.) DOAI552/541, Oxygen bonded directly at the 1-, 2-, or 4-position552/6539,10-Seco-cyclopentanohydrophenanthrene ring system or 9,10-seco cyclopentanohydrophenanthrene ring system having a bond between the 3- and 5-positions (e.g., vitamin D compounds, cholecalciferols, activated 7-dehydrocholesterols, dihydrotachysterols, 3,5 cyclovitamin D compounds, etc.)ExaminersPrimary: Schenkman, LeonardAssistant: Lipovsky, Joseph A. Attorney, Agent or FirmInternational ClassC07C 401/00 (20060101)AbstractThis invention is directed to new 26-homo-vitamin D compounds, to methods for preparing the same and novel intermediate compounds.The compounds are characterized by vitamin D-like activity of the order of 1,25-dihydroxyvitamin D3, the recognized circulating hormonal form of vitamin D, or various of its derivatives and by greater antineoplastic activity than such compounds but without their attendant calcemic activity. The compounds are useful in the treatment of disease states characterized by calcium-phosphorous imbalances and where antineoplastic activity is indicated. |
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