Process for preparing 1--hydroxy cholesterol derivatives
Synthesis of steroids
Synthesis of 1,25-dihydroxyergocalciferol
Sidechain homo-vitamin D compounds with preferential anti-cancer activity Patent #: 4717721
ApplicationNo. 06/835711 filed on 03/03/1986
US Classes:514/167, 9,10-seco- cyclopentanohydrophenanthrene ring system (e.g., vitamin D, etc.) DOAI552/541, Oxygen bonded directly at the 1-, 2-, or 4-position552/6539,10-Seco-cyclopentanohydrophenanthrene ring system or 9,10-seco cyclopentanohydrophenanthrene ring system having a bond between the 3- and 5-positions (e.g., vitamin D compounds, cholecalciferols, activated 7-dehydrocholesterols, dihydrotachysterols, 3,5 cyclovitamin D compounds, etc.)
ExaminersPrimary: Schenkman, Leonard
Assistant: Lipovsky, Joseph A.
Attorney, Agent or Firm
International ClassC07C 401/00 (20060101)
AbstractThis invention is directed to new 26-homo-vitamin D compounds, to methods for preparing the same and novel intermediate compounds.The compounds are characterized by vitamin D-like activity of the order of 1,25-dihydroxyvitamin D3, the recognized circulating hormonal form of vitamin D, or various of its derivatives and by greater antineoplastic activity than such compounds but without their attendant calcemic activity. The compounds are useful in the treatment of disease states characterized by calcium-phosphorous imbalances and where antineoplastic activity is indicated.