U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents

Patent 4847290 Issued on July 11, 1989. Estimated Expiration Date: Icon_subject August 17, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Application

No. 07/086274 filed on 08/17/1987

US Classes:

514/454, Tricyclo ring system having the hetero ring as one of the cyclos514/455Chalcogen bonded directly to ring carbon of the hetero ring

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 31/35 (20060101)

Abstract

A non-psychoactive metabolite of THC is described. The invention is based on the discovery that this metabolite has analgesic and anti-inflammatory properties. The use of the metabolite as a therapeutic agent is based upon the further discovery that it is non-ulcerogenic.

Other References

  • Burstein, S. et al., Biochemical Pharmacology, 35:2553-2558, 1986
  • Burstein, S. et al., Experientia, 43:402-403, 1987
  • Sophia, R. D. et al., The Journal of Pharmacology and Experimental Therapeutics, 186:646-655, 1973
  • Sophia, R. C. et al., Pharmacology, 17:79-82, 1978
  • Watanabe, K. et al., European Journal of Pharmacology, 63:1-6, 1980
  • Widman et al., Metabolism of Delta-1-Tetrahydrocannabinol in Man, in: Pharmacokinetics and Pharmacodynamics of Psychoacive Drugs, Eds. G. Barnett and C. N. Chiang, Biomed. Publ., Forest City, California, 1985
  • Perez-Reyes, M. Pharmacodynamics of Certain Drugs of Abuse, in: Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, Eds. G. Barnett and C. N. Chiang, Biomed. Publ., Forest City, California, 1985
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