U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Orally administerable sustained release pharmaceutical formulations

Patent 4847092 Issued on July 11, 1989. Estimated Expiration Date: Icon_subject August 19, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 07/233771 filed on 08/19/1988

US Classes:

424/456, Gelatin424/457Sustained or differential release

Examiners

Primary: Page, Thurman K.
Assistant: Horne, Leon R.

Attorney, Agent or Firm

International Class

A61K 9/48 (20060101)

Abstract

This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.

Other References

  • Chemical Abstracts, vol. 89: 80177 "Effect of Hydrophilization of Hydrophobic on Release Rate for Capsule", Terk, C. F. et al. J. Phar. Science 1978 67 (7), 935-9
  • Chemical Abstracts, vol. 91, 1979: 27262c "in vitro and in vivo Availability of Hydrophilized Phentoine from Capsule", Terk, C. F. et al. J. Phar. Sci. 1979, 68 (5) 634-8
  • Product Bulletin, "The Hard Capsule with the Soft Centre", Elanco Products
  • Product Bulletin, "Gelucire.RTM.", Gattefosse Corporation (1983)
  • Francois et al., Pharm. Ind, 44, 1, 86-89 (1982)
  • Hunter et al., Pharm. Ind., 44, 1, 90-91 (1982)
  • Hunter et al., Pharm. Ind. 45, 4, 433-434 (1983)
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