Oxidized analogs of 17ଲ-N-monosubstituted-carbamoyl-4-aza-5--androstan-3-ones
Patent 4845104 Issued on July 4, 1989. Estimated Expiration Date: 
November 20, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 20, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTaurine and glycine derivatives N-substituted-17ଲ-carbamoylandrost-4-en-3-one 5 reductase inhibitors Preparation of 4-aza-17-substituted-5-androstan-3-ones useful as 5-reductase inhibitors Steroidic 5-reductase inhibitors 17ଲ-N-monosubstituted carbamoyl-4-aza-5-androst-1-en-3-ones which are active as testosterone 5-reductase inhibitors Patent #: 4760071 InventorsAssigneeApplicationNo. 06/932550 filed on 11/20/1986US Classes:514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos514/859, Acne546/77The six-membered hetero ring shares ring members with one other cyclo onlyExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmInternational ClassC07J 73/00 (20060101)AbstractThe compounds of formula (I) ##STR1## wherein R is selected from hydrogen, methyl or ethyl, and R1 is C1-12 straight or branched chain alkyl wherein one of the hydrogens is substituted by hydroxy, carboxylic acid or C1-4 alkyl ester, and A is --CH2 --CH2 or --CH=CH--, and pharmaceutical formulations of the above compounds are active as testosterone 5-reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.Other References
Field of SearchNitrogen containing hetero ring |
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