Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes
Patent 4845081 Issued on July 4, 1989. Estimated Expiration Date: 
September 12, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 12, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorAssigneeApplicationNo. 06/906468 filed on 09/12/1986US Classes:514/232.2, Additional hetero ring attached directly or indirectly to the morpholines by nonionic bonding514/274, Chalcogen bonded directly to pyrimidine at 2-position514/947, Topical application544/256, Four ring nitrogens in the bicyclo ring system544/272, Nitrogen attached directly or indirectly to the purine ring system by nonionc bonding544/276, Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding544/277, Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding544/313, Halogen attached directly to the diazine ring by nonionic bonding544/317, The nitrogen is bonded directly at 4- or 6-position544/82Additional nitrogen containing hetero ring (e.g., thiazole, etc.)ExaminersPrimary: Lee, Mary C.Assistant: Howard, Mary Sue Attorney, Agent or FirmInternational ClassesC07D 239/00 (20060101)C07D 239/46 (20060101) C07D 239/553 (20060101) C07H 19/06 (20060101) C07D 475/08 (20060101) C07H 19/00 (20060101) C07D 473/00 (20060101) C07D 475/00 (20060101) C07D 473/08 (20060101) AbstractN-methylamino derivatives of biologically active substances which have enhanced delivery across topical membranes and pharmaceutical compositions adapted for topical administration containing same.Other References
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