Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals
Patent 4843086 Issued on June 27, 1989. Estimated Expiration Date: 
November 23, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 23, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References4,5 or 6-Alkylaminoalkyl-2-alkyl-4,5,6,7-tetrahydro benzo[d]thiazoles Patent #: 4337343 Inventors
AssigneeApplicationNo. 07/124197 filed on 11/23/1987US Classes:514/367, Bicyclo ring system having the thiazole ring as one of the cyclos514/217.1, Chalcogen is one of the ring hetero atoms514/233.8, Plural ring hetero atoms in the bicyclo ring system514/321Plural hetero atoms in the polycyclo ring systemExaminersPrimary: Gerstl, RobertAttorney, Agent or FirmInternational ClassesC07D 277/82 (20060101)C07D 277/00 (20060101) Foreign Application Priority Data1984-12-22 DEAbstractThis invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms.R2 represents a hydrogen atom or an alkyl group,R3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms,R4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR3 and R4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R1 or R3 or both groups R1 and R3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.Other References
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