Method of increasing tear production by topical administration of cyclosporin
Patent 4839342 Issued on June 13, 1989. Estimated Expiration Date: September 3, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
The present invention provides a method of treating an aqueous-deficient dry eye state in a patient suffering therefrom, which method includes the step of administering cyclosporin topically to the patient's eye. The cyclosporin is administered as a solution, suspension or ointment in a pharmaceutically acceptable excipient.
Other References
Kaswan et al., Am. J. Vet. Res. 46, 376-383 (1985)
Wenger, Synthesis of Cyclosporin and Analogues, pp. 14-25 in Cyclosporin vol. 1, Grune & Stratton, Inc. (New York, 1983)
BenEzra et al., Amer. J. Ophthalmol. 101, 278-282 (1986)
Hunter et al., Clin. Exp. Immunol. 45, 173-177 (1981)
Boisjoly et al., Arch. Ophthalmol. 102, 1804-1807 (1984)
Mosteller et al., Investigative Ophthalmol. Supp. 25, 3, 38 (1984)
Nussenblat et al., Amer. J. Ophthalmol. 96, 275-282 (1983)
Hoffman, et al., Kin. Mbl. Augenheilk. 187, 92-95 (1985) and certified translation thereof
"Aspirin Therapy in Vernal Conjunctivitis" by Abelson, et al., Amer. J. Opthal. 95,502-505 (1983)
"Cryosurgery in the Management of Vernal Keratoconjunctivitis" by Abiose, et al., Annals of Ophthal. 15(8), 744-747 (1983)
"Vernal Conjunctivitis" by Allansmith, Chapter 9, pp. 1-8 Clinical Opthalmology, vol 4, (Harper & Row 1986)
"Cyclosporine Eyedrops for the Treatment of Severe Vernal Keratoconjunctivitis" BenEzra, et al. Amer. J. Opthal. 101, 278-282 (1986)
"Diagnosis and Treatment of Tear Deficiencies" Lemp, Chapter 14, pp. 1-10
September 3, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
