Compositions containing ibuprofen
Patent 4837031 Issued on June 6, 1989. Estimated Expiration Date: 
September 17, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 17, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesL-ascorbic acid tablets Directly compressible acetaminophen granulation Aspirin tablet Process for preparing granulate containing poorly compressible medicinally active matter Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing Direct tableting acetaminophen compositions Patent #: 4661521 InventorApplicationNo. 07/097850 filed on 09/17/1987US Classes:424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/490, Coated (e.g., microcapsules)424/492, Gelatin424/494, Cellulose derivatives424/497Containing solid synthetic polymersExaminersPrimary: Dixon, William R. Jr.Assistant: Brunsman, David Attorney, Agent or FirmInternational ClassesA61K 9/16 (20060101)A61K 9/20 (20060101) A61K 31/19 (20060101) A61K 31/185 (20060101) AbstractA granular composition containing 2-(4-isobutylphenyl)propionic acid (ibuprofen) as an active anti-inflammatory pharmaceutical ingredient as a major component, together with carboxymethylcellulose, a lubricant and water as minor components, is disclosed. Particles of ibuprofen and carboxymethylcellulose are both fluidized and coated with an aqueous disperson of a starch binder. After being dried to a moisture level of about 1-5% and blended with a lubricant and additional carboxymethylcellulose, the resulting granules can be directly molded into a pharmaceutically acceptable tablet having high hardness, short disintegration time and fast dissolution rate. | |
