U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Transdermal drug delivery device

Patent 4837027 Issued on June 6, 1989. Estimated Expiration Date: Icon_subject August 9, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3598122

3598123

3870593

3923939

Slow release copper toxicant compositions
Patent #: 4012221
Issued on: 03/15/1977
Inventor: Walker ,   et al.

Device consisting of copolymer having acetoxy groups for delivering drugs
Patent #: 4144317
Issued on: 03/13/1979
Inventor: Higuchi ,   et al.

Method and composition for the long term controlled release of a non-persistent organotin pesticide from an inert monolithic thermoplastic material
Patent #: 4166111
Issued on: 08/28/1979
Inventor: Cardarelli

Osmotic bursting drug delivery device
Patent #: 4177256
Issued on: 12/04/1979
Inventor: Michaels ,   et al.

Therapeutic system for administering drugs to the skin
Patent #: 4286592
Issued on: 09/01/1981
Inventor: Chandrasekaran

Dissolution controlled active agent dispenser
Patent #: 4314557
Issued on: 02/09/1982
Inventor: Chandrasekaran

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Inventors

Assignee

Application

No. 07/230211 filed on 08/09/1988

US Classes:

424/449, Transdermal or percutaneous424/486Synthetic polymer

Examiners

Primary: Page, Thurman K.
Assistant: Horne, L.

Attorney, Agent or Firm

International Class

A61K 9/70 (20060101)

Abstract

A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

Other References

  • Narkis et al, "Slow Release of Water-Soluble Salts from Polymers"; Journal of Applied Polymer Science, vol. 20, pp. 3431-3436 (1976)
  • Ebert et al, "Development of a Novel Transdermal System Design", Abstract from the Third International Symposium on Recent Advances in Drug Delivery Systems, Feb. 24-29, 1987, Salt Lake City, Utah
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