Erythropoietin composition

Patent 4835260 Issued on May 30, 1989. Estimated Expiration Date:

March 20, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Manufacture and expression of structural genes
Patent #: 4652639
Issued on: 03/24/1987
Inventor: Stabinsky

Oxidation-resistant muteins Patent #: 4752585
Issued on: 06/21/1988
Inventor: Koths , et al.

Inventor

Shoemaker, Charles B.

Assignee

Genetics Institute, Inc.

Application

No. 07/028282 filed on 03/20/1987

US Classes:

530/397, Glycoprotein hormones435/365.1, Expressing recombinant lymphokine, interferon, hormone, growth factor or morphogen435/69.4, Hormones and fragments thereof514/21, Produced by or extracted from animal tissue514/8, Glycoprotein (carbohydrate containing)514/814, ANEMIA530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/380, Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc.530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/399, Hormones, e.g., prolactin, thymosin, growth factors, etc.530/829, Blood530/830, Plasma; serum536/23.51Hormone

Examiners

Primary: Moskowitz, Margaret
Assistant: Kushan, Jeff

Attorney, Agent or Firm

International Classes

C07K 14/435 (20060101)
C07K 14/505 (20060101)
A61K 38/00 (20060101)

Abstract

A new improved glycoprotein having erythropoietin-type activity is disclosed. The substrate is characterized by amino acid sequence substantially identical to the amino acid sequence of native human erythropoietin wherein the methionine-54 is replaced with leucine. DNA encoding for the EPO-substance and expression vectors incorporating the same are disclosed. Therapeutic compositions and methods for treatment of anemic conditions are described.

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