Controlled release pharmaceutical composition
Patent 4834985 Issued on May 30, 1989. Estimated Expiration Date: 
May 19, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 19, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2921883 3082154 3084294 3147187 3492397 3922339 Process of making a synthetic resin product containing a molecular inclusion compound in cyclodextrin Patent #: 4722815 InventorsAssigneeApplicationNo. 07/052585 filed on 05/19/1987US Classes:424/488, Polysaccharides (e.g., cellulose, etc.)424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/484, Matrices424/490, Coated (e.g., microcapsules)424/494, Cellulose derivatives424/499, Contains proteins or derivative or polysaccharides or derivative424/502, Contains waxes, higher fatty acids, higher fatty alcohols514/58, Dextrin or derivative514/965, Discrete particles in supporting matrix514/971, Crystallization point depressant or cold stabilizer containing536/103Dextrin or derivativeExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmInternational ClassA61K 9/20 (20060101)Foreign Application Priority Data1986-06-05 GBClaimsWhat is claimed is:1. A solid, controlled release pharmaceutical composition comprising a pharmaceutically active ingredient incorporated in a matrix comprising a first substance selected fromthe group consisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C12 -C36 fatty alcohol and a polyalkylene glycol. 2. The composition according to claim 1 wherein the first substance is a cyclodextrin. 3. The composition according to claim 2 wherein the first substance is a beta-cyclodextrin. 4. The composition according to claim 1 wherein the fatty alcohol is a C14 -C22 fatty alcohol. 5. The composition according to claim 1 wherein the fatty alcohol is selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol and myristyl alcohol. 6. The composition according to claim 1 wherein the polyalkylene glycol is polyethylene glycol. 7. The composition according to claim 1 wherein the first substance is a cellulose ether. 8. The composition according to claim 7 wherein the cellulose ether is at least one of a hydroxyalkylcellulose and a carboxyalkylcellulose. 9. The composition according to claim 1 wherein the ratio of the first substance to the second substance is between 6 to 1 and 1 to 6. 10. The composition according to claim 9 wherein the ratio is between 4 to 1 and 1 to 4. 11. The composition according to claim 1 wherein the composition contains between 1% and 80% (w/w) of the first substance. 12. The composition according to claim 11 wherein the composition contains between 1% and 50% (w/w) of the first substance. 13. The composition according to claim 12 wherein the composition contains between 2% and 40% (w/w) of the first substance. 14. The composition according to claim 1 wherein the active ingredient is a water isoluble drug. 15. A preparation in which a pharmaceutically active ingredient can be incorporated for the production of a solid, controlled release, pharmaceutical composition, said preparation comprising a matrix of a first substance selected from the groupconsisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C12 -C36 fatty alcohol and a polyalkylene glycol. 16. The preparation according to claim 15 wherein the first substance is a cyclodextrin. 17. The preparation according to claim 16 wherein the first substance is a beta-cyclodextrin. 18. The preparation according to claim 15 wherein the fatty alcohol is a C14 -C22 fatty alchol. 19. The preparation according to claim 18 wherein the fatty alcohol is selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol and myristyl alcohol. 20. The preparation according to claim 15 wherein the polyalkylene glycol is polyethylene glycol. Field of SearchNatural gums, resin or latexContaining waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof Contains waxes, higher fatty acids, higher fatty alcohols Matrices Polysaccharides (e.g., cellulose, etc.) Sustained or differential release Containing discrete coated particles pellets, granules, or beads Sustained or differential release type Discrete particles in supporting matrix Coated (e.g., microcapsules) Cellulose derivatives Contains proteins or derivative or polysaccharides or derivative |
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