Crystalline penicillin derivative tosylate hydrates
Patent 4831025 Issued on May 16, 1989. Estimated Expiration Date: 
March 13, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 13, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesBis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide Patent #: 4244951 InventorsAssigneeApplicationNo. 07/024858 filed on 03/13/1987US Classes:514/195, 3-position substituent contains -COOC- group540/315, Processes utilizing penam containing compound540/336The -C(=X)- group, an unsubstituted benzene ring and -NHH bonded directly to the same carbon atom (e.g., ampicillin, etc.)ExaminersPrimary: Killos, Paul J.Assistant: Clarke, Vera C. Attorney, Agent or FirmInternational ClassC07D 499/00 (20060101)Foreign Application Priority Data1980-10-31 GBAbstractThe present invention relates to a crystalline hydrate of a salt of the antimicrobial agent 1,1-dioxopenicillanoyloxymethyl 6-(D--amino--phenylacetamido)penicillanate with p-toluenesulfonic acid, more particularly the mono- and dihydrate.The hydrates are easily obtained in a crystalline state devoid of organic solvent residues, they show good stability on storage, they are effectively absorbed and hydrolyzed in vivo, and they are thus specifically suitable for medical treatment of patients, in particular for oral administration.Field of SearchProcesses utilizing penam containing compound |
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