Controlled absorption pharmaceutical formulation
November 12, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesGranule having controlled release properties Retard form of pharmaceuticals with insoluble porous diffusion coatings Quinidine sustained release dosage formulation Extended action controlled release compositions Retard form of pharmaceuticals with insoluble porous diffusion coatings Constant release rate solid oral dosage formulations of quinidine Method for preparing a pharmaceutical controlled release composition Retard form of pharmaceuticals with insoluble porous diffusion coatings Pharmaceutical multiple-units formulation Diffusion coated multiple-units dosage form InventorsAssigneeApplicationNo. 06/930138 filed on 11/12/1986US Classes:424/458, Containing discrete coated particles pellets, granules, or beads424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/470Where particles are granulatedExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassesA61K 9/50 (20060101)A61K 31/49 (20060101) Foreign Application Priority Data1985-11-13 IEAbstractA controlled absorption quinidine formulation for oral administration comprises a pellet having a core of quinidine or a pharmaceutically acceptable salt thereof in association with an organic acid and optionally other excipients, and an outer membrane which permits release of quinidine in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XXI at 37° C. and 75 r.p.m. is not more than 15% after one hour of measurement. Not more than 50% of the total quinidine is release after a total of 4 hours of measurement, not more than 80% is released after a total of 8 hours of measurement and not less than 90% release is achieved after a total of 24 hours. | |
