Effervescent couples, histamine H2 -antagonist effervescent compositions containing them and their preparation
Patent 4824664 Issued on April 25, 1989. Estimated Expiration Date: 
January 20, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 20, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 1764996 2147743 3887700 Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use Chemical compounds Cimetidine Z, a new crystal modification of cimetidine Patent #: 4537900 InventorsAssigneeApplicationNo. 07/004725 filed on 01/20/1987US Classes:424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/439, Food or edible as carrier for pharmaceutical424/44, Gas produced in situ by chemical reaction424/446Medicated gauze padsExaminersPrimary: Robinson, Ellis P.Assistant: Ryan, J. P. Attorney, Agent or FirmInternational ClassA61K 9/46 (20060101)Foreign Application Priority Data1986-01-22 FRAbstractThe invention relates to an effervescent couple which comprises a mixture of mono-and di-alkali metal citrate as well as to a process for preparing same. The process comprises partially neutralizing citric acid by reacting an alkali metal carbonate or bicarbonate with citric acid and water and controlling the amount of carbon dioxide released during the reaction by stopping the reaction when a certain amount of citric acid has been neutralized. In a preferred embodiment the reaction is stopped when from about 24% to about 54% of the potential amount of carbon dioxide has been released. | |
