Heterocyclic compounds
Patent 4816470 Issued on March 28, 1989. Estimated Expiration Date: 
March 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3 amino alkyl indoles for use in treating migraine Indole-5-acetamides for treatment of migraine 5-substituted 3-aminoalkyl indoles useful in treatment of migraine Patent #: 4672067 InventorsAssigneeApplicationNo. 06/789831 filed on 11/15/1985US Classes:514/415, The bicyclo ring system consists of the five-membered hetero ring and a benzene ring (e.g., indole, etc.)548/504, Nitrogen attached indirectly to ring carbon of the five-membered hetero ring by acyclic nonionic bonding (e.g., tryptamine, etc.)548/505The nitrogen is double or triple bonded directly to carbonExaminersPrimary: Ceperley, Mary E.Attorney, Agent or FirmInternational ClassesC07D 209/00 (20060101)C07D 209/16 (20060101) C07D 209/24 (20060101) C07D 209/10 (20060101) C07D 209/18 (20060101) C07D 209/48 (20060101) Foreign Application Priority Data1982-06-07 GBAbstractIndole derivatives of the general formula (I) are disclosed: ##STR1## where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group;R3 is H or an alkyl group;R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; andAlk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes.These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner.Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process. |
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