Patent 4816255 Issued on March 28, 1989. Estimated Expiration Date: July 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
This invention relates to a composition for use in the treatment of fibrocystic dysplasia which may reduce or dissipate cyst formation in the female breast and alleviate the pain and discomfort associated with this disease. More particularly, this invention relates to a composition for the treatment of fibrocystic dysplasia which is comprised of a solution of elemental iodine (I2). For the purposes of this application, elemental iodine refers to diatomic iodine (I2) which may also be referred to as metallic iodine or iodine metal. The elemental iodine is soluble in water, that leaves it thermodynamically free. The term "aqueous iodine" may also be used to refer to such an aqueous solution.
Other References
Chem. Abst. 75:17655p (1971)--Eskin
Chem. Abst. 84:126,316k (1976)--Stringer et al
Chem. Abst. 90:135,752a (1979)--Eskin
Chem. Abst. 94:41160m (1981)--Bloomer et al
Chem. Abst. 99:136,212x (1983)--Bloomer et al
Chem. Abst. 101:126,735r (1984)--Song et al
Eskin B. A.--Iodine Metabolism and Breast Cancer, Transactions of the New York Academy of Science, 1970, 32(8), 911-47, See also Chem. Abstracts, at 75: 17655p (1971)
Moss et al., Invest. Radiol. 7, 335 (Jul.-Aug. 1972)
Zak et al., J. Am. Pharm. Ass. Sci. 41, 260 (1952)
Eskin et al., Int. J. Gyn-Obs. 8, 232 (1970)
U.S. Pharmacopea XVIII, p. 733 (1970)
Banfield et al., J. Am. Can. Inst. 46, 269 (1971)
Hetzel, D. S.--Iodine Deficiency Disorders (I.D.D.) and their Eradication, Lancet 12, Nov. 1983, pp. 1126-1129
Eskin, B. A.--Iodine and Breast Cancer-A 1982 Update, Biological Trace Element Research 5, 1983, pp. 399-412
Honour, A. J., N. B. Bryant et al--Secretion of Radio Iodine in Digestive Juices and Milk in Man, Clinical Science 11, 1952; pp. 447-462
Beatson, G. T.--On the Treatment of Inoperable Cases of Carcinoma of the Mamma: Suggestions for a New Method of Treatment with Illustrative Cases, Lancet 2, 1896, pp. 162-165
Kelly, F. C. and Snedden, W. W.--Prevalence and Geographical Distribution of Indemic Goitre, W.H.O. Monograph, 44; pp. 27-233
Eskin, B. A.--Iodine Metabolism and Breast Cancer--Transactions of the New York Academy of Sciences, Series II, vol. 32, 1970; pp. 911-947
Vishnyakova, V. V. et al--On the Treatment of Dyshormonal Hyperplasia of Mammary Glands, Vestin. Akad. Med. Mauk. S.S.S.R. 21:19, 1966
Roberts, M. M. et al.--Risk of Breast Cancer in Women with History of Benign Disease of the Breast--British Medical Journal, Jan. 28, 1984, vol. 288; pp. 275-278
Peacock, Jr., Erlee--Management of Benign Disease of the Breast--American Surgeon, 1978, vol. 44(10): pp. 626-630
Haagensen, C. D.--Disease of the Breast, Second Edition, W. B. Saunders 1971; pp. 380-383
Gairard, B., et al--Proteins and Ionic Components in the Breast Cyst Fluid, Endocrinology of Cystic Breast Disease, Raven Press, 1983, pp. 191-195
Gros, Ch., et al--Classification Thermographique des Cancers Mammaires--Bull Cancer (Paris) 58; pp. 351-362, 1971
Spratt, J. S. et al--Association of Chronic Cystic Mastopathy, Xeromammographic Patterns and Cancer (prepublication)
Cole, E. N., et al--Is Prolactin a Fluid and Electrolyte Regulating Hormone in Man, J. Physiology, 1975, 252
Cole, E. N., R. A. Gillwood et al--Serum Prolactin Concentrations in Benign Breast Disease Throughout the Menstrual Cycle, Europ. J. Cancer, vol. 13, pp. 597-603
Minton, J. P., et al--Caffeine, Cyclic Nucleotides and Breast Disease, Surgery 1979, 86:105-109
Fratkin, L. B.--The Hyperestrogen State, Paper presented at the North Pacific Surgery Meeting, Tacoma, Washington, 1980. (unpublished)
Moosa, A. R. et al--Thyroid Status and Breast Cancer--Royal College of Surgeons, England 53, 1973
Greenblatt, R. B. et al--Danazol in the Treatment of Mammary Dysplasia, Fertility and Sterility 34, 1980. pp. 242-245
Eskin, B. A. et al--Human Breast Uptake of Radioactive Iodine, Obstetrics and Gynecology vol. 44, No. 3, Sep. 1985, pp. 398-402
Eskin, B. A.--Thyroid Hormones and Tumor Development--Chapter 6, Influences of Hormones in Tumor Development, pp. 129-156
Riggs, D. S. et al--Investigations on the Nature of Blood Iodine
Yunbing, G. et al--Clinical Observation of 174 Cases of Hyperplastic Cystic Disease of Breast Treated with Traditional Chinese Medicine, Journal of Traditional Chinese Medicine 3(4), 1983; pp. 291-294
Amalric, R. et al--Dysplasies Fibro-Kystiques Aspects Thermographiques et Radiographiques, Senologia 2: 1977, 45-51
July 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
