Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
Patent 4814183 Issued on March 21, 1989. Estimated Expiration Date: 
August 31, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 31, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3854770 3916899 Novel drug delivery device Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina Osmotic system with distribution zone for dispensing beneficial agent Prolonged release pharmaceutical preparations Microporous-semipermeable laminated osmotic system Process for manufacturing device with dispersion zone Patent #: 4285987 InventorAssigneeApplicationNo. 07/091571 filed on 08/31/1987US Classes:424/485, Natural gums, resin or latex424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/444, Resorbable by the body424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488Polysaccharides (e.g., cellulose, etc.)ExaminersPrimary: Dixon, William R. Jr.Assistant: Griffis, Andrew Attorney, Agent or FirmInternational ClassA61K 9/00 (20060101)AbstractThe instant invention is directed to a drug delivery device for the controlled release of beneficial agents and drugs into an environment of use comprising:(A) a core composition comprising(a) a water insoluble, non-diffusible charged resin entity, and(b) a diffusible, water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and(B) a substantially imperforate water-insoluble wall surrounding said core composition, prepared from a semipermeable material substantially impermeable to the core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a hole(s) for release of the therapeutic agent through the water insoluble wall.Other References
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