U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Remote administration of hyaluronic acid to mammals

Patent 4808576 Issued on February 28, 1989. Estimated Expiration Date: Icon_subject April 28, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Treatment for warts
Patent #: 4055660
Issued on: 10/25/1977
Inventor: Meierhenry

Ultrapure hyaluronic acid and the use thereof
Patent #: 4141973
Issued on: 02/27/1979
Inventor: Balazs

Method for stimulating phagocytic activity and synergistic compositions therefor
Patent #: 4272522
Issued on: 06/09/1981
Inventor: Balazs

Therapeutic dimethyl sulfoxide composition and methods of use
Patent #: 4296104
Issued on: 10/20/1981
Inventor: Herschler

Pharmaceutical compositions
Patent #: 4427649
Issued on: 01/24/1984
Inventor: Dingle ,   et al.

Hyaluronic acid from bacterial culture
Patent #: 4517295
Issued on: 05/14/1985
Inventor: Bracke ,   et al.

Antitumor agent Patent #: 4521406
Issued on: 06/04/1985
Inventor: Kawamura ,   et al.

Inventors

Assignee

Application

No. 06/856732 filed on 04/28/1986

US Classes:

514/54, Polysaccharide514/825, ARTHRITIS536/55.1Polysaccharides

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

International Classes

A61K 31/715 (20060101)
A61K 9/08 (20060101)
A61K 9/00 (20060101)
C08B 37/00 (20060101)
C08B 37/08 (20060101)

Abstract

The present disclosure is concerned with the discovery that hyaluronic acid, an agent well known to reduce the sequelae of trauma in mammalian joint tissue when applied directly to the traumatized tissue, will be carried to such traumatized tissue by the mammal's natural processes if applied at a site remote from the traumatized tissue. Thus, hyaluronic acid, in any therapeutically acceptable form, can be administered by the typical remote routes including intravenous, intramuscular, subcutaneous and topical.This makes the utilization of hyaluronic acid much more convenient and attractive. For instance the treatment of arthritis in horse or human joints with hyaluronic acid no longer requires more difficult intra articular injections.

Other References

  • Chemical Abstracts, Band 102, Nr.11, Mar. 18, 1985, Nr. 89817, Columbus, Ohio, "Studies on Analgesic and Anti-Inflammatory Effects of Sodium Hyaluronate"
  • Chemical Abstracts, Band 106, Nr.7, Feb. 16, 1987, Nr. 4352Ou, Columbus, Ohio, "Topical Treatment of Experimental Skin Lesions in Rats"
  • Preliminary Clinical Assessment of NaHyaluronate Injection Into Human Arthritic Joints, by Peyron et al, vol. 22, No. 8, pp. 731-736, Oct., 1974
  • Decreased Granulation Tissue Reaction After Installment of Hyaluronic Acid, by Rydell, pp. 307-311, vol. 41, of Acta Orthop Scandinav
  • Letter in Veterinary Medicine, pp. 446-447, Apr. 1984 Issue
  • Influence of a Glycosaminoglycan Polysulfate on Iysosomal Enzyme Release from Human Polymorphonuclear Leukocytes, vol. 41, pp. 50-53, 1982
  • Polysulfated Glycosaminoglycan: A New Intra-Articular Treatment for Equine Lameness, Vet. Medicine, pp. 811-816, Jun. 1984
  • Clinical Orthopaedics, pp. 25-32, Oct., 1971, No. 80, by Rydel et al, "Effect of Intra-Articular Injection of Hyaluronic Acid on Clinical Symptoms"
  • Influences of Sulfated Glycosaminoglycans on Biosynthesis of Hyaluronic Acid in Rabbit Knee Synovial Membrane, by Nishikawa, pp. 146-153, Jul. 1985, vo. 240
  • Vergleich von Glykosaminoglykanpolysulfat und Physiologischer Kochsalzlosung bei Arthorosen Grober Gelenke, pp. 223-228, vol. 42, Jul. 1983
  • Die Tierexperimentelle Gonartrose der Ratte und Ihre Therapie mit Glykoaminoglykan Polysulfat, pp. 100-107, vol. 44, 1985
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