U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method and compositions for modulating neovascularization

Patent 4808402 Issued on February 28, 1989. Estimated Expiration Date: Icon_subject May 29, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
Patent #: 4457916
Issued on: 07/03/1984
Inventor: Hayashi ,   et al.

Angiotropins of leukocytes and inflamed tissue, process for their biotechnical preparation, and pharmaceutical compositions thereof
Patent #: 4465669
Issued on: 08/14/1984
Inventor: Wissler ,   et al.

Controlled release formulation
Patent #: 4666705
Issued on: 05/19/1987
Inventor: DeCrosta ,   et al.

CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression Patent #: 4721672
Issued on: 01/26/1988
Inventor: Vallee ,   et al.

Inventors

Assignee

Application

No. 07/056554 filed on 05/29/1987

US Classes:

424/78.06, Skin burn or open wound treatment424/423, Surgical implant or material424/618, Silver424/85.1, LYMPHOKINE514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/21, Produced by or extracted from animal tissue514/8Glycoprotein (carbohydrate containing)

Examiners

Primary: Schofer, Joseph L.
Assistant: Kulkosky, Peter F.

International Classes

A61K 38/19 (20060101)
A61L 17/00 (20060101)
A61L 15/16 (20060101)
A61L 15/32 (20060101)
A61L 26/00 (20060101)

Abstract

Tumor necrosis factors possess the unexpected ability to induce angiogenesis, or neovascularization. Novel methods and TNF-containing compositions and articles are provided for the induction of neovascularization and rapid wound healing.

Other References

  • Chem. Abstract vol. 106, entry 100647
  • Chem. Abstract vol. 105, entry 207395
  • Chem. Abstract vol. 105 entry 224304b
  • Chem. Abstract vol. 104 entry 4515
  • Scientific American vol. 258 May 1988 pp. 67-75
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